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Published on: August 2, 2024
[Expression of THY1 gene in epithelial ovarian cancer]
Li-qin Zeng1, Zhi-lan Peng, Zhen-ling Duan
1Department of Gynecology, Guangdong Women's and Children's Hospital and Health Institute, Guangzhou 510010, China. zenglq89@163.com
Objective:
To detect the expession of THY1 in ovarian serous cystadenocarcinoma tissues.
Methods:
Immunohistochemistry was performed to detect the expression of THY1 gene in formalin-fixed, paraffin-embedded specimens of normal ovaries (n = 25), ovarian serous cystadenoma (n = 25), and serous cystadenocarcinoma (n = 53). The correlation of THY1 expression with clinicopathological parameters was statistically analyzed.
Results:
The positive expression rates of THY1 protein in normal ovaries, ovarian serous cystadenomas and ovarian serous cystadenocarcinomas were 60.0% (15/25), 72.0% (18/25) and 34.0% (18/53), respectively. The values of IOD of THY1 protein expression were 288,449.2 +/- 60,087.3, 271,655.6 +/- 66,588.7 and 252,087.6 +/- 45,559.4, respectively. The expression of THY1 protein was significantly down-regulated in ovarian serous cystadenocarcinoma tissues compared with that in normal ovarian tissues and ovarian serous cystadenoma tissues (P < 0.05). THY1 expression was negatively correlated with surgical-pathological staging, histological differentiation and lymph node involvement (P < 0.05).
Conclusion:
The decreased level of THY1 expression may be related with the occurrence and development of ovarian serous cystadenocarcinoma.
