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A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
Published on: February 28, 2012
Implantable cardioverter-defibrillator prescription in the elderly
Andrew E Epstein1, G Neal Kay, Vance J Plumb
1University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. aepstein@uab.edu
Insights
Over 40% of new implantable cardioverter-defibrillators (ICDs) are implanted in patients over 70, with many older recipients not meeting CRT-D criteria. Cardiac death rates were similar, but noncardiac mortality increased with age.
Area of Science:
- Cardiology
- Geriatric Medicine
- Medical Devices
Background:
- Sudden cardiac death risk rises with age, suggesting elderly benefit from implantable cardioverter-defibrillators (ICDs).
- Elderly patients are underrepresented in clinical trials, potentially limiting understanding of ICD benefits in this demographic.
- Comorbid conditions in older adults may influence the effectiveness of ICDs.
Purpose of the Study:
- To investigate the prescription patterns of ICDs in elderly patient populations.
- To compare ICD implantation trends between the Advancements in ICD Therapy (ACT) Registry and the National Cardiovascular Data Registry (NCDR).
Main Methods:
- Comparison of patient demographics, implantation indications, and device types between the ACT Registry and NCDR datasets.
- Analysis of age distribution, primary prevention rates, and single-chamber ICD use across different age groups.
- Evaluation of two-year mortality rates and causes of death in relation to patient age and ICD implantation.
Main Results:
- Over 40% of new ICDs and cardiac resynchronization therapy defibrillators (CRT-Ds) were implanted in patients older than 70 years.
- A significant proportion of elderly patients, particularly those aged 80 and above, received devices for primary prevention.
- While noncardiac death was more frequent in older patients, cardiac death rates remained similar across age groups.
Conclusions:
- The study highlights a substantial implantation rate of ICDs and CRT-Ds in elderly individuals (>70 years).
- A notable percentage of older patients receiving CRT-Ds did not meet established implantation criteria.
- Noncardiac mortality is a more significant concern in older ICD recipients, whereas cardiac mortality shows no significant age-related difference.
Background:
Because sudden cardiac death increases with age, implantable cardioverter-defibrillators (ICDs) might greatly benefit the elderly. However, elderly patients are underrepresented in clinical trials, and comorbid conditions may attenuate benefit.
Objective:
The purpose of this study was to examine ICD prescription in the elderly.
Methods:
The ages, indications, and implanted ICD type of patients enrolled in the Advancements in ICD Therapy (ACT) Registry were compared to those from the National Cardiovascular Data Registry (NCDR).
Results:
The ACT Registry included 4,566 patients who underwent first ICD or cardiac resynchronization therapy ICD (CRT-D) implantation. Among these patients, 2.6% were 18-39 years old, 8.6% were 40-49 years, 20.1% were 50-59 years, 27.6% were 60-69 years, 29.0% were 70-79 years, and 12.0% were >or=80 years. In the six age groups, 82.5%, 79.4%, 77.3%, 80.1%, 77.7%, and 74.6% received devices for primary prevention, and single-chamber ICDs were implanted in 41.4%, 42.8%, 38.7%, 33.8%, 25.2%, and 28.1%, respectively (P <.0001). Two-year mortality rates increased incrementally from 5.80% to 17.80% in the six groups (P <.05). Noncardiac death was more common in older than in younger patients. Among patients >or=80 years old receiving a CRT-D, 78% had QRS duration and New York Heart Association class that met accepted implantation criteria. Age distribution, indication, and type of device were similar in the ACT Registry and in 74,476 patients in the NCDR.
Conclusion:
More than 40% of new ICDs and CRT-Ds are implanted in patients >70 years old and more than 10% in patients >or=80 years old. A significant proportion of those receiving a CRT-D did not fulfill accepted criteria for implantation. Noncardiac death occurred more frequently in older patients, but cardiac death rates were similar.
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