Implantable cardioverter-defibrillator prescription in the elderly

Andrew E Epstein1, G Neal Kay, Vance J Plumb

  • 1University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. aepstein@uab.edu

Heart Rhythm
|June 23, 2009
PubMed

Insights

Over 40% of new implantable cardioverter-defibrillators (ICDs) are implanted in patients over 70, with many older recipients not meeting CRT-D criteria. Cardiac death rates were similar, but noncardiac mortality increased with age.

Area of Science:

  • Cardiology
  • Geriatric Medicine
  • Medical Devices

Background:

  • Sudden cardiac death risk rises with age, suggesting elderly benefit from implantable cardioverter-defibrillators (ICDs).
  • Elderly patients are underrepresented in clinical trials, potentially limiting understanding of ICD benefits in this demographic.
  • Comorbid conditions in older adults may influence the effectiveness of ICDs.

Purpose of the Study:

  • To investigate the prescription patterns of ICDs in elderly patient populations.
  • To compare ICD implantation trends between the Advancements in ICD Therapy (ACT) Registry and the National Cardiovascular Data Registry (NCDR).

Main Methods:

  • Comparison of patient demographics, implantation indications, and device types between the ACT Registry and NCDR datasets.
  • Analysis of age distribution, primary prevention rates, and single-chamber ICD use across different age groups.
  • Evaluation of two-year mortality rates and causes of death in relation to patient age and ICD implantation.

Main Results:

  • Over 40% of new ICDs and cardiac resynchronization therapy defibrillators (CRT-Ds) were implanted in patients older than 70 years.
  • A significant proportion of elderly patients, particularly those aged 80 and above, received devices for primary prevention.
  • While noncardiac death was more frequent in older patients, cardiac death rates remained similar across age groups.

Conclusions:

  • The study highlights a substantial implantation rate of ICDs and CRT-Ds in elderly individuals (>70 years).
  • A notable percentage of older patients receiving CRT-Ds did not meet established implantation criteria.
  • Noncardiac mortality is a more significant concern in older ICD recipients, whereas cardiac mortality shows no significant age-related difference.
Abstract

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...