Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Influence of Cognition on Affect

The Influence of Cognition on Affect

Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be interpreted as...

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Viloxazine occupies the 5-HT2C receptor in the macaca fascicularis brain in vivo: A [11C]CIMBI-36 positron emission tomography study.

The international journal of neuropsychopharmacology·2026

Same author

Regional variability in the associations between social and health-related risk factors and memory across Europe.

Scientific reports·2026

Same author

The serotonin transporter and the serotonin 1B receptor in relation to social cognition in healthy adults.

EJNMMI research·2026

Same author

The Binding of the High Affinity Radioligand Fallypride to the D2-dopamine Receptor is Sensitive to Injected Mass - a PET Study in Rodents.

Molecular imaging and biology·2026

Same author

Cohort Profile Update: Survey of Health, Ageing and Retirement in Europe: Biomarker data for age-related health conditions.

medRxiv : the preprint server for health sciences·2026

Same author

A <sup>68</sup>Ga-/Gd labeled PET/MR imaging probe for pH assessment.

EJNMMI research·2026

Same journal

Decoding neuronal criticality firing patterns for large brain based EEG models.

NeuroImage·2026

Same journal

Segmentation of the parasagittal dura mater on multi-center 3D-FLAIR MRI.

NeuroImage·2026

Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026

Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026

Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026

Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

Modulation of striatal dopamine D1 binding by cognitive processing.

Sari Karlsson¹, Lars Nyberg, Per Karlsson

¹Aging Research Center, Karolinska Institutet, Gävlegatan 16, SE-113 30 Stockholm, Sweden. sari.karlsson@ki.se

|June 23, 2009

Summary

This summary is machine-generated.

Cognitive activity reduces dopamine D1 receptor binding in younger adults, but not in older adults. This suggests aging alters dopamine system modifiability and receptor availability.

More Related Videos

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Published on: December 5, 2025

Related Experiment Videos

Last Updated: Jun 22, 2026

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Published on: December 5, 2025

Area of Science:

Neuroscience
Cognitive Science
Radiology

Background:

Dopamine (DA) plays a crucial role in higher-order cognitive functions.
The modifiability of D1 receptor binding by cognitive activity remains debated.

Purpose of the Study:

To investigate whether cognitive activity alters striatal D1 receptor binding potential (BP).
To compare these effects in younger and older adults.

Main Methods:

Positron Emission Tomography (PET) with [(11)C] SCH 23390 was used to measure striatal D1 BP.
Measurements were taken at rest and during an inhibitory cognitive task in 20 younger and 20 older adults.

Main Results:

Younger adults exhibited significant task-related reductions in D1 BP across sensorimotor, limbic, and associative striatum.
Older adults showed no reliable task-related D1 BP reductions in any striatal subregion.

Conclusions:

D1 receptor binding is modifiable by cognitive activity in younger individuals.
Human aging is associated with reduced dopamine receptor density and altered dopamine system modifiability.