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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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[Acromegaly in the elderly].

O Dupuy1, P Petrossians, T Brue

  • 1Service d'endocrinologie et maladies métaboliques, HIA Bégin, 69, avenue de Paris, 94160 Saint-Mandé, France. oliver-dupuy2@wanadoo.fr

Annales D'Endocrinologie
|June 23, 2009
PubMed
Summary
This summary is machine-generated.

Elderly acromegaly patients show higher rates of diabetes and hypertension. Despite less surgery, their disease control is similar to younger patients, validating treatment choices.

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Area of Science:

  • Endocrinology
  • Geriatric Medicine
  • Rare Disease Research

Context:

  • Multicentric registers are crucial for studying rare disorders like acromegaly.
  • The French Acromegaly Register provides valuable data on patient characteristics.
  • Understanding acromegaly in the elderly population is essential due to unique clinical challenges.

Purpose:

  • To analyze the clinical, hormonal, and therapeutic profiles of acromegaly patients over 70 years old.
  • To compare elderly acromegaly patients with a younger cohort to assess medical management similarities.
  • To investigate the prevalence of comorbidities and treatment outcomes in older acromegalic individuals.

Summary:

  • The study analyzed 68 elderly acromegaly patients (≥70 years) from the French Acromegaly Register.
  • Elderly patients exhibited higher frequencies of diabetes and hypertension compared to younger patients.
  • Despite lower surgical rates (44% vs. 90%), disease control at 1 year was comparable (51%) in both age groups.

Impact:

  • Highlights the significant prevalence of comorbidities like diabetes and hypertension in elderly acromegaly patients.
  • Demonstrates that effective disease control can be achieved in older individuals, even with less frequent surgical intervention.
  • Confirms the efficacy of chosen treatments for managing acromegaly across different age groups, particularly in the elderly.