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Related Experiment Video

Updated: Jun 22, 2026

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem
08:16

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem

Published on: December 30, 2015

[(3)H]-YM-09151-2 binding sites in human brain postmortem.

Donatella Marazziti1, Stefano Baroni, Irene Masala

  • 1Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy. dmarazzi@psico.med.unipi.it

Neurochemistry International
|June 23, 2009
PubMed
Summary

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Dopamine D4 receptors are sparsely distributed in the human hippocampus, with higher densities of D2/D3 and sigma receptors in the prefrontal cortex and striatum. This study clarifies D4 receptor labeling in brain tissue.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Neurochemistry

Background:

  • Limited data exists on dopamine D4 receptor distribution in the human brain.
  • Understanding receptor density is crucial for neuropharmacological research.

Purpose of the Study:

  • To investigate the density and pharmacological characteristics of dopamine D4 receptors.
  • To map D4 receptor distribution in the human prefrontal cortex, striatum, and hippocampus.

Main Methods:

  • Utilized autopsy brain samples from seven human subjects.
  • Performed binding assays using [(3)H]-YM-09151-2, a D2-like receptor antagonist.
  • Employed L-745,870, sulpiride, and PPAP to block non-specific and sigma receptor binding.

Main Results:

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Last Updated: Jun 22, 2026

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem
08:16

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem

Published on: December 30, 2015

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue
10:58

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue

Published on: October 1, 2008

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
15:26

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

  • A low density of dopamine D4 receptors was observed exclusively in the hippocampus.
  • The prefrontal cortex and striatum showed a predominance of D2/D3 and sigma receptors.
  • [(3)H]-YM-09151-2 successfully labeled D4 receptors when other receptors were blocked.

Conclusions:

  • Dopamine D4 receptors have a limited distribution in the human brain, primarily in the hippocampus.
  • Effective labeling of D4 receptors requires blocking D2, D3, and sigma receptors.
  • These findings provide critical insights for neuroimaging and drug development targeting D4 receptors.