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In utero eye development documented by fetal MR imaging
L B Paquette1, H A Jackson, C J Tavaré
1Division of Neonatology, Institute of Maternal and Fetal Health, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
AJNR. American Journal of Neuroradiology
|June 23, 2009
Summary
Fetal eye development, including lens, interocular distance, and globe growth, follows a quadratic model, slowing toward the end of gestation. These parameters can be measured using fetal MRI.
Area of Science:
- Medical imaging
- Fetal development
- Ophthalmology
Background:
- Limited research exists on ocular abnormalities and growth parameters via fetal MRI.
- Fetal eye development is crucial for understanding congenital conditions.
Purpose of the Study:
- To determine the relationship between fetal eye development parameters and gestational age.
- To utilize fetal MRI for assessing ocular growth.
Main Methods:
- Retrospective study of 127 fetuses with normal CNS.
- Measured transverse globe diameter, interocular distance, and lens diameter using fetal MRI.
- Applied Loess curves and statistical models to analyze growth patterns.
Main Results:
- Fetal eye growth, including lens, interocular distance, and globe diameter, follows a quadratic model.
- Lens and interocular distance growth plateau around 36 weeks gestation.
- Globe growth plateaus around 42 weeks gestation.
Conclusions:
- Fetal MRI effectively demonstrates lens, orbit, and interocular distance growth.
- All measured parameters indicate a quadratic growth model, with slowed growth near term.
- Findings provide normative data for fetal eye development assessment.
