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Updated: Jun 22, 2026
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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Inflammation in renal transplantation.
Sadollah Abedini1, Ingar Holme, Winfried März
1Renal Section, Department of Medicine, Toensberg County Hospital, Toensberg, Norway. Sadollah.abedini@gmail.com
Summary
Inflammation markers, including interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP), are linked to increased cardiovascular events and mortality in renal transplant recipients.
Area of Science:
- Nephrology
- Cardiology
- Immunology
Background:
- Renal transplant recipients have a higher risk of premature cardiovascular disease and death.
- The relationship between inflammation, mortality, and cardiovascular events in this population requires further investigation in large-scale studies.
Purpose of the Study:
- To examine the association between inflammation markers and cardiovascular outcomes in renal transplant recipients.
- To investigate the link between interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) with all-cause mortality and cardiovascular events.
Main Methods:
- The ALERT study was a randomized, double-blind, placebo-controlled trial involving 2102 renal transplant recipients.
- The study analyzed the association between baseline IL-6 and hsCRP levels and cardiovascular events and all-cause mortality during a 5- to 6-year trial with a 2-year extension.
Main Results:
- Elevated baseline levels of IL-6 were independently associated with an increased risk of major cardiac events (HR 1.08, P=0.018) and all-cause mortality (HR 1.11, P<0.001).
- Increased hsCRP levels were also independently associated with a higher risk of cardiovascular events (HR 1.10, P=0.027) and all-cause mortality (HR 1.15, P=0.049).
Conclusions:
- Inflammation markers, specifically IL-6 and hsCRP, are significant independent predictors of cardiovascular events and all-cause mortality in renal transplant recipients.
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