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[Pneumococcal meningitis. 6-year review].

M L Aísa1, A Esteban, C Villuendas

  • 1Servicio de Microbiología, Hospital Miguel Servet, Zaragoza.

Enfermedades Infecciosas Y Microbiologia Clinica
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

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Pneumococcal meningitis treatment in adults and children showed high rates of penicillin resistance. Vancomycin proved effective for penicillin-resistant strains, offering a crucial therapeutic option.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Pneumococcal meningitis remains a significant cause of morbidity and mortality.
  • Underlying conditions and anatomical defects are common in patients with pneumococcal meningitis.
  • Antimicrobial resistance, particularly to penicillin, poses a challenge in treatment.

Purpose of the Study:

  • To evaluate treatment outcomes for pneumococcal meningitis.
  • To assess the efficacy of various antibiotics, including vancomycin, against penicillin-resistant Streptococcus pneumoniae strains.
  • To identify effective therapeutic options for pneumococcal meningitis.

Main Methods:

  • Retrospective review of 29 pneumococcal meningitis cases over a 6-year period (1983-1988).

Related Experiment Videos

  • Analysis of patient demographics, underlying conditions, and anatomical defects.
  • Microbiological analysis including Gram stain, latex test, and minimum inhibitory concentrations (MICs) for various antibiotics.
  • Evaluation of treatment regimens and clinical responses.

    • Main Results:

    • Penicillin resistance was observed in a significant proportion of isolates.
    • Vancomycin, rifampin, and cefotaxime demonstrated sensitivity against all isolated strains.
    • Vancomycin achieved clinical and microbiological cure in 10 out of 12 patients treated for penicillin-resistant pneumococcal meningitis.
    • Treatment failures with cefotaxime and moxalactam were successfully resolved with vancomycin.

    Conclusions:

    • Vancomycin is a valuable therapeutic option for treating pneumococcal meningitis caused by penicillin-resistant strains.
    • Early identification of antimicrobial resistance patterns is crucial for effective treatment selection.
    • Further research into optimal treatment strategies for resistant pneumococcal meningitis is warranted.