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Vibration effects of lab equipment on dissolution testing with USP paddle method

Zongming Gao1, Andrea Thies, William Doub

  • 1Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St Louis, Missouri 63101, USA. zongming.gao@fda.hhs.gov

Journal of Pharmaceutical Sciences
|June 23, 2009
PubMed
Summary

Environmental vibrations significantly impact dissolution testing results. Accelerometer measurements showed that root mean square (RMS) acceleration above 0.01 g, vertically or horizontally, typically affected dissolution outcomes.

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