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Updated: Jun 22, 2026
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Case report: bilateral simultaneous central retinal vein occlusion in Waldenström's macroglobulinemia
Bhuvan Chanana1, Nitin Gupta, Raj Vardhan Azad
1All India Institute of Medical Sciences, New Delhi, India. bhuvan_chanana@rediffmail.com
Background:
We report a case of bilateral simultaneous central retinal vein occlusion (CRVO) in Waldenström's macroglobulinemia.
Methods:
We report the case of a 60-year-old woman who presented with decreased vision in both eyes.
Results:
Ophthalmoscopic examination showed scattered retinal hemorrhages and venous tortuosity with macular edema bilaterally. The patient had a history of hypertension and was under investigation for lethargy, recurrent epistaxis, and fainting episodes. Serum protein electrophoresis showed an M-spike in the gamma region. Bone marrow trephine biopsy confirmed the diagnosis of Waldenström's macroglobulinemia. The patient was treated with plasmapheresis and subsequent chemotherapy, resulting in improvement of ocular and systemic symptoms.
Conclusions:
We report this case to emphasize that in any case of bilateral CRVO, hyperviscosity should be suspected. Serum electrophoresis along with coagulation profiles should be performed as a standard practice in patients with bilateral simultaneous CRVO.
