Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Influences on Intelligence

Biological Influences on Intelligence

Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter more...

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Gut-Brain Axis

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The role of subjective distress in contextualizing testosterone-cortisol coupling.

Psychoneuroendocrinology·2026

Same author

Becoming a mother leaves long-lasting molecular memories.

Nature·2026

Same author

Autism subtypes identified using cross-species functional connectivity analyses.

Nature neuroscience·2026

Same author

Loss of enteric BDNF-TrkB signaling and VIPergic dysfunction underlie gastrointestinal dysmotility in a <i>Mecp2-null</i> mouse model of Rett syndrome.

bioRxiv : the preprint server for biology·2026

Same author

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids.

Nature communications·2026

Same author

Association between chronic stress and the epigenome: Exploration of psychological and biological stress.

PloS one·2026

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Epigenetic influences on brain development and plasticity.

Michela Fagiolini¹, Catherine L Jensen, Frances A Champagne

¹F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, CLS 13034, Boston, MA 02115, United States.

Current Opinion in Neurobiology

|June 24, 2009

Summary

This summary is machine-generated.

Epigenetic mechanisms link sensory experiences to brain development, influencing gene expression and shaping behaviors. Understanding these processes could enhance brain plasticity in adulthood.

More Related Videos

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

Related Experiment Videos

Last Updated: Jun 22, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

Area of Science:

Neuroscience
Developmental Biology
Epigenetics

Background:

Brain development involves intricate interactions between genetic factors and sensory input.
Epigenetic regulation of gene expression is crucial for adapting to environmental stimuli during development.

Purpose of the Study:

To explore the role of epigenetic mechanisms in mediating the effects of sensory experience on neuronal circuit development.
To understand how environmental factors influence gene expression during critical developmental periods.

Main Methods:

The study reviews recent evidence on epigenetic modifications.
It focuses on the molecular and cellular changes underlying developmental plasticity.

Main Results:

Epigenetic regulation acts as a bridge between environmental stimuli and lasting changes in molecular, cellular, and behavioral phenotypes.
These mechanisms are key to understanding developmental plasticity.

Conclusions:

Understanding epigenetic regulation offers insights into the formation of critical periods in brain development.
This knowledge may lead to strategies for enhancing brain plasticity and promoting adaptive changes in adults.