Advanced oxidation protein products in obstructive sleep apnea
1Department of Neurology, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic. ksonka@lf1.cuni.cz
Prague Medical Report
|June 25, 2009
Summary
Obstructive sleep apnea (OSA) is linked to increased oxidative stress and the development of atherosclerosis. While not statistically significant in this study, Advanced Oxidation Protein Products (AOPP) showed a correlation with the apnea-hypopnea index.
Area of Science:
- Cardiology
- Sleep Medicine
- Biochemistry
Background:
- Obstructive sleep apnea (OSA) is a recognized risk factor for hypertension, coronary artery disease, and stroke.
- OSA is implicated in accelerating atherogenesis, the process of plaque buildup in arteries.
- Advanced Oxidation Protein Products (AOPP) are biochemical markers associated with increased atherogenesis risk and coronary artery disease.
Purpose of the Study:
- To investigate the relationship between obstructive sleep apnea (OSA) and oxidative stress markers.
- To determine if AOPP levels are elevated in men with OSA.
- To explore the correlation between AOPP and the severity of OSA, measured by the apnea-hypopnea index (AHI).
Main Methods:
- Twenty men diagnosed with OSA were studied.
- Night polygraphy was used to assess sleep apnea severity (AHI).
- Morning blood samples were analyzed for Advanced Oxidation Protein Products (AOPP) concentrations.
Main Results:
- The mean AOPP concentration in the OSA group was 91.8 micromol/l, compared to 76.2 micromol/l in the control group; this difference was not statistically significant.
- A significant positive correlation was found between AOPP levels and the apnea-hypopnea index (R=0.485, P=0.030).
Conclusions:
- The findings support the hypothesis that OSA contributes to increased oxidative stress.
- OSA may play a role in promoting atherogenesis, as indicated by the correlation between AOPP and AHI.
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