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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 22, 2026

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
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A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

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Modulating the tumor microenvironment to improve radiotherapy.

Amit Maity1

  • 1Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. maity@xrt.upenn.edu

Retina (Philadelphia, Pa.)
|June 26, 2009
PubMed
Summary
This summary is machine-generated.

Radiotherapy

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Area of Science:

  • Oncology and Ophthalmology

Background:

  • Radiotherapy's antiangiogenic effects are limited by increased vascular endothelial growth factor (VEGF).
  • This VEGF upregulation is a known challenge in cancer treatment.
  • Understanding this mechanism is crucial for treating neovascular eye diseases.

Purpose of the Study:

  • To explore the relevance of radiotherapy's effects on vascular endothelial growth factor (VEGF) in oncology.
  • To discuss the potential application of these findings to age-related macular degeneration (AMD) treatment.

Main Methods:

  • Review of existing research on radiotherapy and VEGF in oncology.
  • Analysis of parallels between cancer neovascularization and retinal neovascularization in AMD.

Main Results:

  • Radiotherapy can damage vascular tissue but stimulates proangiogenic signals like VEGF.
  • Targeting growth factors alongside radiation is a strategy explored in oncology.

Conclusions:

  • Strategies combining radiotherapy with anti-VEGF agents in oncology may inform AMD treatment.
  • Further research into these combined approaches could offer new therapies for retinal diseases.