Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative efficacy and side effects of the treatment of euthyroid goiter with levo-thyroxine or triiodothyroacetic acid.

The Journal of clinical endocrinology and metabolism·2003
Same author

[Interaction of caffeine with basic nucleic acids my a molecular mechanic method].

Biofizika·2003
Same author

[Possible configuration of dimers of Gua-Cyt bases. Computation by molecular mechanic models and density functional theory].

Biofizika·2003
Same author

Methodologies for determining capture efficiencies in surface treatment tanks.

AIHA journal : a journal for the science of occupational and environmental health and safety·2003
Same author

Results of kidney transplantation in recipients over 70 years of age: experience at a single center.

Transplantation proceedings·2003
Same author

Helical computed tomography angiography is the most efficient test to assess vascular calcifications in the iliac arterial sector in renal transplant candidates.

Transplantation proceedings·2003
Same journal

[Position statement of the Spanish Society of Nephrology on the SARS-CoV-2 vaccines].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2024
Same journal

[Real-world experience with mild-moderate COVID-19 therapies in kidney transplant patients: How to treat patients with chronic kidney disease from now on?]

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2023
Same journal

[Tixagevimab-cilgavimab as pre-exposure prophylactic treatment against SARS-CoV-2 in kidney transplantation patients].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2023
Same journal

[Characterization of hospitalized patients with acute kidney injury associated with COVID-19 in Spain: Renal replacement therapy and mortality. FRA-COVID SEN Registry Data].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2023
Same journal

Acute interstitial nephritis following COVID-19 vaccination.

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2023
Same journal

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2022
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
09:27

The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat

Published on: June 17, 2016

[Fibrate-induced deterioration of renal function].

N Polanco1, E Hernández, E González

  • 1Department of Nephrology. 12 de Octubre University Hospital. Madrid, Spain. nipolanco@yahoo.es

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|June 26, 2009
PubMed
Summary
This summary is machine-generated.

Fibrate medications can cause acute kidney injury, with some patients experiencing irreversible renal function loss. Regular kidney function monitoring is crucial, especially for those with chronic renal failure, during fibrate therapy.

Related Experiment Videos

Last Updated: Jun 22, 2026

The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
09:27

The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat

Published on: June 17, 2016

Area of Science:

  • Nephrology
  • Pharmacology
  • Internal Medicine

Context:

  • Fibrates are commonly prescribed for hyperlipidemia.
  • Adverse effects on renal function are not widely recognized.
  • A significant number of patients experienced acute renal failure linked to fibrate use.

Purpose:

  • To analyze the clinical experience of acute renal failure associated with fibrate medications.
  • To identify risk factors and outcomes in patients developing renal impairment.

Summary:

  • A retrospective review identified thirteen patients with acute renal failure attributed to fibrates (Fenofibrate, Bezafibrate, Gemfibrozil).
  • Ten patients received Fenofibrate, one Bezafibrate, and two Gemfibrozil.
  • Over 74% increase in serum creatinine was observed.
  • Acute renal failure was reversible in nine patients, but four had persistent renal dysfunction.
  • Patients with poorer outcomes had higher creatinine levels and longer exposure to fibrates.
  • Renal biopsies showed no significant lesions.

Impact:

  • Fibrate therapy can precipitate acute renal failure, with a notable percentage of patients (30.8%) not recovering baseline renal function.
  • Highlights the importance of renal function monitoring during fibrate treatment, particularly in patients with pre-existing chronic renal failure.