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Published on: July 23, 2016
[Target-controlled infusion. Clinical relevance and special features when using pharmacokinetic models]
H Ihmsen1, S Schraag, S Kreuer
1Anästhesiologische Klinik, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen. Harald.Ihmsen@kfa.imed.uni-erlangen.de
Der Anaesthesist
|June 26, 2009
Summary
Target-controlled infusion (TCI) systems offer advanced intravenous anaesthetic delivery. This review clarifies TCI pharmacokinetic models and covariates to aid clinicians in optimizing anaesthetic dosing for improved patient care.
Area of Science:
- Anesthesiology
- Pharmacokinetics
- Clinical Pharmacology
Context:
- Target-controlled infusion (TCI) systems have been commercially available since 1996.
- Modern TCI systems incorporate numerous features and options, potentially complicating usage for less experienced clinicians.
- Understanding the nuances of TCI is crucial for safe and effective anesthetic management.
Purpose:
- To review and explain the scientific concepts underlying modern TCI systems.
- To differentiate between various pharmacokinetic models and modes of application.
- To elucidate the impact of covariates on TCI dosing and clinical practice.
Summary:
- This review details the distinctions between pharmacokinetic models and application modes in TCI systems.
- It examines the influence of covariates on drug delivery and anesthetic outcomes.
- The text aims to clarify the scientific principles and practical implications for TCI system users.
Impact:
- Empowers clinicians to make informed decisions regarding TCI system selection and parameter adjustment.
- Facilitates a deeper understanding of TCI technology for improved anesthetic drug administration.
- Aims to enhance the safe and effective use of TCI in clinical anesthesia practice.
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