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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
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Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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Related Experiment Video

Updated: Jun 22, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilic colitis.

Nnenna Okpara1, Bassam Aswad, Gyorgy Baffy

  • 1Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, MA 02130, United States.

World Journal of Gastroenterology
|June 26, 2009
PubMed
Summary

Eosinophilic colitis (EC) is a rare gastrointestinal disease presenting variably in neonates and young adults. While often confused with other conditions, EC responds well to treatments like steroids, antihistamines, and biologics.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pediatrics

Background:

  • Eosinophilic colitis (EC) is a rare primary eosinophilic gastrointestinal disease with bimodal prevalence in neonates and young adults.
  • EC is less understood than eosinophilic esophagitis, presenting with variable clinical features based on inflammation depth.
  • The differential diagnosis is broad, including infections, allergies, IBD, and connective tissue disorders.

Purpose of the Study:

  • To review the clinical presentation, differential diagnosis, and management of eosinophilic colitis.
  • To highlight the importance of identifying secondary causes of colon eosinophilia.
  • To discuss current and emerging treatment strategies for EC.

Main Methods:

  • Literature review of primary eosinophilic gastrointestinal diseases, focusing on eosinophilic colitis.
  • Analysis of clinical presentations and diagnostic challenges.
  • Evaluation of treatment responses to various therapeutic agents.

Main Results:

  • Eosinophilic colitis exhibits diverse clinical presentations depending on the extent of inflammation (mucosal, transmural, or serosal).
  • Accurate diagnosis requires excluding secondary causes of eosinophilia such as parasitic infections, drug reactions, IBD, and connective tissue diseases.
  • EC demonstrates a significant response to corticosteroid therapy.

Conclusions:

  • Eosinophilic colitis requires careful differential diagnosis to identify and treat secondary causes.
  • Steroids are effective, but steroid-sparing agents like antihistamines, leukotriene inhibitors, and biologics offer alternative management options.
  • Further research is needed to fully elucidate the pathophysiology and optimize long-term management of EC.