Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recurrence Score® gene group components and outcomes in the RxPONDER trial (SWOG S1007).

Journal of the National Cancer Institute·2026
Same author

Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

The Journal of experimental medicine·2026
Same author

The global cancer workforce crisis: a shared responsibility, a united front.

The Lancet. Oncology·2026
Same author

Long-term follow-up of S0221, comparing alternative dose-schedules of anthracycline and taxane therapy in early breast cancer.

JNCI cancer spectrum·2026
Same author

The Pathologic Response Evaluation and Detection in Circulating Tumor-DNA Study: Ultrasensitive Circulating Tumor-DNA Assessment of Breast Cancer Minimal Residual Disease.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Exposure to GLP-1RA and Risk of Structural Progression in Differentiated Thyroid Cancer.

The Journal of clinical endocrinology and metabolism·2026

Related Experiment Video

Updated: Jun 22, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

NCCN Task Force Report: Bone Health in Cancer Care.

Julie R Gralow1, J Sybil Biermann, Azeez Farooki

  • 1Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance, Seattle, Washington, USA.

Journal of the National Comprehensive Cancer Network : JNCCN
|June 27, 2009
PubMed
Summary

Cancer patients face increased osteoporosis risk and bone metastases. The National Comprehensive Cancer Network (NCCN) task force reviewed strategies for managing bone health, preventing skeletal events, and reducing cancer recurrence in bones.

More Related Videos

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Related Experiment Videos

Last Updated: Jun 22, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Area of Science:

  • Oncology
  • Bone Metabolism
  • Cancer Survivorship

Background:

  • Bone health is crucial in cancer care, with patients experiencing increased osteoporosis risk due to treatments like chemotherapy, aromatase inhibitors, androgen-deprivation therapy, and glucocorticoids.
  • The skeleton is a frequent site for metastatic cancer recurrence, leading to significant morbidity from skeletal-related events.

Framework:

  • The National Comprehensive Cancer Network (NCCN) established a multidisciplinary task force focused on Bone Health in Cancer Care.
  • The task force aimed to advance screening and therapeutic options for treatment-related bone loss.
  • Key areas included understanding bone metastases, managing skeletal metastases, and reducing bone recurrences.

Implementation:

  • The report summarizes presentations from an NCCN task force meeting.
  • Discussions focused on current progress and evolving strategies in bone health management for cancer patients.

Implications:

  • Improved management of bone health can enhance cancer survivorship and reduce treatment-related complications.
  • Further research and clinical strategies are needed to address bone metastases and recurrence effectively.