Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Implicit Memories01:24

Implicit Memories

Implicit memories, also known as non-declarative memories, are long-term memories that function outside of conscious awareness. These memories influence behavior and skills without explicit knowledge. This type of memory is evident in tasks like playing tennis, snowboarding, and texting. Implicit memory has three subsystems: procedural memory, conditioning, and priming. This type of memory is essential in various activities, from everyday tasks to specialized skills.
One key aspect of implicit...
Traumatic Memory01:20

Traumatic Memory

Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual remembers mundane...
Elaborative Rehearsals01:07

Elaborative Rehearsals

Elaborative rehearsal is a crucial cognitive strategy that strengthens information encoding in long-term memory by making meaningful connections between new data and pre-existing knowledge. This approach contrasts with maintenance rehearsal, which involves simple repetition without delving into the significance of the information. While maintenance rehearsal might temporarily keep information active in short-term memory, it is less effective for long-term retention.
The effectiveness of...
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is critical for...
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Naturalistic behavior and self-generated neural activity predictive of self-correction.

bioRxiv : the preprint server for biology·2026
Same author

A Novel Cooperative Behavior Assay in Rats Reveals Distinct Social Coordination Strategies of Increasing Complexity and Social Reciprocity Deficits in a Model of Fragile X Syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Regional specialization in prefrontal cortex manifests in the reliability of task progression codes.

Neuron·2026
Same author

Meta-learning is expressed through altered prefrontal cortical dynamics.

bioRxiv : the preprint server for biology·2026
Same author

Sensorimotor Theta Oscillations Coordinate Speech Movements.

bioRxiv : the preprint server for biology·2025
Same author

RealtimeDecoder: A Fast Software Module for Online Clusterless Decoding.

eNeuro·2025
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
Same journal

Microglial fitness in moderation: Tuning TREM2 signaling through Ptpn6.

Neuron·2026
Same journal

Human astrocytes keep time with inflammation.

Neuron·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

Reactivating memories for consolidation.

Shantanu P Jadhav1, Loren M Frank

  • 1W.M. Keck Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA.

Neuron
|June 27, 2009
PubMed
Summary
This summary is machine-generated.

Memory consolidation relies on hippocampal-neocortical dialogue during sharp-wave ripples. CA3 output is crucial for contextual fear memory consolidation, with its absence reducing ripple-related reactivation.

More Related Videos

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
11:17

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear

Published on: August 24, 2012

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker
08:32

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker

Published on: December 18, 2014

Related Experiment Videos

Last Updated: Jun 22, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
11:17

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear

Published on: August 24, 2012

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker
08:32

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker

Published on: December 18, 2014

Area of Science:

  • Neuroscience
  • Memory Research
  • Systems Neuroscience

Background:

  • Memory consolidation is theorized to involve hippocampal-neocortical interactions.
  • Reactivation of memory traces in the hippocampus during sharp-wave ripples is a proposed mechanism.

Discussion:

  • Nakashiba et al. investigate the role of CA3 output in memory consolidation.
  • The study examines the impact of CA3 output on contextual fear memory formation.
  • Ripple-related reactivation in the hippocampus is analyzed in relation to CA3 function.

Key Insights:

  • CA3 output from the hippocampus is essential for the consolidation of contextual fear memories.
  • A lack of CA3 output leads to diminished ripple-related reactivation.
  • This provides direct evidence linking CA3-dependent reactivation to memory consolidation.

Outlook:

  • Further research can explore the precise molecular mechanisms of CA3 involvement.
  • Investigating other memory types and their consolidation processes is warranted.
  • Understanding hippocampal-neocortical dialogue offers therapeutic targets for memory disorders.