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Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
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Related Experiment Video

Updated: Jun 22, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

Aripiprazole-induced hiccups: a case report.

Prasenjit Ray¹, Mohammad Zia Ul Haq, S Haque Nizamie

¹Central Institute of Psychiatry, Ranchi, India.

General Hospital Psychiatry

|June 27, 2009

Summary

Aripiprazole, an atypical antipsychotic, can cause hiccups in patients with bipolar disorder. This rare side effect may involve neurotransmitter pathways, highlighting the need for careful monitoring.

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Drug-induced hiccups are a known adverse effect of various medications.
Neurotransmitters like dopamine, serotonin, and GABA are implicated in hiccup generation.
Atypical antipsychotics are increasingly used for mood disorders.

Observation:

A patient with organic bipolar affective disorder developed persistent hiccups.
The hiccups emerged after the initiation of aripiprazole treatment.
No other causative factors for the hiccups were identified.

Findings:

Aripiprazole, an atypical antipsychotic, is a potential cause of drug-induced hiccups.
The mechanism may involve alterations in dopaminergic, serotonergic, or GABAergic pathways.

Related Experiment Videos

Last Updated: Jun 22, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

This case highlights a rare adverse drug reaction associated with aripiprazole.

Implications:

Clinicians should consider aripiprazole as a potential cause of hiccups in patients with bipolar disorder.
Further research is needed to elucidate the precise neurobiological mechanisms.
Monitoring for and managing drug-induced hiccups is crucial for patient adherence and well-being.