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Intraocular pressure-lowering activity of topical application of Aegle marmelos fruit extract in experimental animal
Renu Agarwal1, Suresh Kumar Gupta, Sushma Srivastava
1Delhi Institute of Pharmaceutical Sciences and Research, New Delhi 110017, India.
Aim:
The present study was designed to evaluate the intraocular pressure (IOP)-lowering activity of topical application of the aqueous extract of Aegle marmelos fruit in experimental animal models.
Materials And Methods:
New Zealand white rabbits with normal and experimentally elevated IOP using water loading and steroid-induced models were included in this study. The IOP-lowering effect of A. marmelos fruit extract in rabbits with experimentally elevated IOP was also compared with that of timolol 0.25%.
Results:
In rabbits with normal IOP, the A. marmelos fruit extract at a concentration of 1% showed the maximum IOP-lowering effect with 22.81% reduction from baseline IOP. The maximum IOP reduction achieved in water loading and steroid-induced models with the same concentration of A. marmelos was 27.57 and 28.41% from baseline, respectively. The efficacy was comparable to that of timolol after 45 min of water loading in the water loading model, and during the first 2 h of treatment in the steroid-induced model.
Conclusion:
A. marmelos fruit extract showed significant IOP-lowering activity in experimental animal models.
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