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Related Experiment Video

Updated: Jun 22, 2026

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Published on: August 16, 2018

Bioactive triterpenoids from Callistemon lanceolatus.

Wonsik Jeong¹, Seong Su Hong, Nahyun Kim

¹School of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Korea.

Archives of Pharmacal Research

|June 27, 2009

Summary

This summary is machine-generated.

Nine triterpenoids were isolated from Callistemon lanceolatus and tested for their effects on nitric oxide production. Betulinic acid 3-O-caffeate demonstrated moderate inhibition, suggesting potential anti-inflammatory properties.

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

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Last Updated: Jun 22, 2026

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

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Published on: August 16, 2018

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Area of Science:

Natural Products Chemistry
Pharmacology

Background:

Callistemon lanceolatus is a plant source of bioactive compounds.
Triterpenoids are a class of natural products with diverse biological activities.
Nitric oxide (NO) plays a key role in inflammatory processes.

Purpose of the Study:

To isolate and characterize triterpenoids from Callistemon lanceolatus.
To evaluate the inhibitory effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 cells.

Main Methods:

Isolation of compounds using spectroscopic techniques, including 1D- and 2D-NMR.
In vitro evaluation of nitric oxide inhibition in murine macrophage RAW264.7 cells stimulated with LPS.

Main Results:

A new triterpenoid, 30-hydroxyalphitolic acid (1), and eight known triterpenoids (2-9) were identified.
Betulinic acid 3-O-caffeate (7) exhibited moderate inhibition of nitric oxide production with an IC(50) value of 15.4 µM.
Other isolated compounds showed minimal or no significant activity.

Conclusions:

Callistemon lanceolatus contains a variety of triterpenoids with potential anti-inflammatory activity.
Betulinic acid 3-O-caffeate is a promising candidate for further investigation as an inhibitor of nitric oxide production.