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Related Experiment Video

Updated: Jun 22, 2026

Crystallization of Membrane Proteins in Lipidic Mesophases

Crystallization of Membrane Proteins in Lipidic Mesophases

Published on: March 28, 2011

Crystal forms of atorvastatin.

Su-Gyeong An¹, Young-Taek Sohn

¹College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea.

Archives of Pharmacal Research

|June 27, 2009

Summary

Researchers discovered a new, stable crystal form of atorvastatin. This new form, isolated through recrystallization, showed no transformation after two years, indicating good physical stability for pharmaceutical applications.

Area of Science:

Solid-state chemistry
Pharmaceutical sciences
Materials science

Background:

Atorvastatin is a widely prescribed statin drug.
Understanding its solid-state properties, including polymorphism, is crucial for drug formulation and efficacy.
Polymorphs can significantly impact a drug's bioavailability and stability.

Purpose of the Study:

To investigate novel polymorphs and pseudopolymorphs of atorvastatin.
To characterize different crystalline forms of atorvastatin.
To assess the stability and transformation of identified crystal forms.

Main Methods:

Recrystallization was employed to isolate distinct crystal forms.
Powder X-ray diffractometry (PXRD) was used for structural characterization.

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Differential scanning calorimetry (DSC) and thermogravimetric analysis (TG) were utilized to assess thermal properties and stability.

Main Results:

Three distinct crystal forms of atorvastatin were successfully isolated.
PXRD and DSC analyses confirmed significant differences between the crystal forms.
A novel crystal form, designated Form 3, was identified.
Form 3 exhibited excellent physical stability, showing no transformation after two years of storage at room temperature.

Conclusions:

A new, physically stable polymorph of atorvastatin (Form 3) has been identified.
This discovery contributes to the understanding of atorvastatin's solid-state landscape.
The inherent stability of Form 3 suggests potential advantages for pharmaceutical formulation and long-term storage.