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Measuring Endoplasmic Reticulum Stress and Unfolded Protein Response in HIV-1 Infected T-Cells and Analyzing its Role in HIV-1 Replication
Published on: June 14, 2024
[Endoplasmic reticulum stress and heart diseases]
Xu Teng1, Yong-Fen Qi, Chao-Shu Tang
1Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing 100034, China.
Abstract:
Endoplasmic reticulum (ER) is a multifunctional organelle responsible for the synthesis and folding of proteins, calcium storage and synthesis of lipid. Perturbations of ER functional homeostasis result in accumulation of misfolded or unfolded protein in ER, which induces a series of cellular responses (ER stress) through proportional signaling pathway. It is reported that ER stress contributes to development of diseases of heart, including myocardial ischemia-reperfusion injury, cardiomyopathy and heart failure, et al. ER stress might be a novel therapeutic target in heart diseases.
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