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Published on: March 14, 2020

[Recent advances on liver X receptors]

Qiang Wang1, Yu Jiang

  • 1Department of Biochemistry, the Faculty of Basic Medicine, the Third Military Medical University, Chongqing 400038, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|June 30, 2009
PubMed

Insights

Liver X receptors (LXRs) regulate cholesterol and fat metabolism, impacting inflammation. Targeting LXRs offers potential for treating metabolic diseases like atherosclerosis and diabetes.

Area of Science:

  • Molecular Biology
  • Metabolic Diseases
  • Immunology

Background:

  • Liver X receptors (LXRs) are nuclear receptors activated by oxysterols.
  • LXRs are key regulators of cholesterol metabolism and homeostasis.
  • LXRs influence lipogenesis, carbohydrate metabolism, and immune responses.

Purpose of the Study:

  • To highlight the multifaceted roles of LXRs.
  • To underscore the significance of LXRs in integrating metabolic and inflammatory signals.
  • To identify LXRs as potential therapeutic targets.

Main Methods:

  • Review of existing literature on LXR function.
  • Analysis of LXR's role in transcriptional control.
  • Examination of LXR's involvement in metabolic and inflammatory pathways.

Main Results:

  • LXRs control cholesterol metabolism and homeostasis.
  • LXRs modulate lipogenesis, carbohydrate metabolism, and macrophage inflammatory responses.
  • LXRs integrate metabolic and inflammatory signaling pathways.

Conclusions:

  • LXRs are crucial for maintaining metabolic balance.
  • The integration of metabolic and inflammatory functions by LXRs is significant.
  • LXRs represent promising therapeutic targets for atherosclerosis, hypercholesterolemia, and type 2 diabetes.

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