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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Related Experiment Video

Updated: Jun 22, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

[Multiple primary melanoma].

J R Ferreres1, A Moreno, J Marcoval

  • 1Servicio de Dermatología, Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, España. joseramonferreresriera@yahoo.es

Actas Dermo-Sifiliograficas
|June 30, 2009
PubMed
Summary
This summary is machine-generated.

The risk of developing a second primary melanoma in a Spanish Mediterranean population is 2.6%. Lifelong skin surveillance is crucial for melanoma patients to detect new primary tumors.

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Area of Science:

  • Dermatology
  • Oncology
  • Epidemiology

Context:

  • Previous studies on multiple primary melanoma risk primarily focused on North American populations.
  • The risk of multiple primary melanoma ranges from 1% to 8% globally.
  • Understanding population-specific risks is vital for targeted screening and management.

Purpose:

  • To determine the incidence and clinical-pathological characteristics of multiple primary melanomas in a Spanish Mediterranean cohort.
  • To compare the risk in this population with existing data from other regions.

Summary:

  • A retrospective study of 934 melanoma patients (1988-2005) identified 25 cases of multiple primary melanoma, yielding a 2.6% risk.
  • The second melanoma often appeared within the first year (50%) and at a different body site (58%) from the initial lesion.
  • While individual lesions within a patient often shared features, significant interindividual histological variability was noted.

Impact:

  • The risk of a second melanoma, though lower than in North America, is significant in this population.
  • Highlights the necessity of lifelong dermatological follow-up for all melanoma patients.
  • Emphasizes the importance of complete skin examinations at each follow-up visit to detect new primary melanomas and metastases.