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Related Concept Videos

Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
Tight Junctions01:29

Tight Junctions

Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...

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Related Experiment Video

Updated: Jun 22, 2026

Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow
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Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow

Published on: August 14, 2014

Junctional trafficking and epithelial morphogenesis.

Frederik Wirtz-Peitz1, Jennifer A Zallen

  • 1Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA.

Current Opinion in Genetics & Development
|June 30, 2009
PubMed
Summary
This summary is machine-generated.

Epithelial cells use vesicle transport to dynamically reorganize E-cadherin, a key adhesion molecule. This process is crucial for cell adhesion, polarity, and tissue remodeling during development.

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Last Updated: Jun 22, 2026

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Biochemistry

Background:

  • Epithelial monolayers form the structural basis of tissues and organs.
  • Cell adhesion molecules like E-cadherin are vital for maintaining tissue integrity.
  • Epithelial cells must actively remodel junctions for tissue development.

Purpose of the Study:

  • To explore the role of vesicle transport in regulating cell adhesion.
  • To understand the dynamics of junctional proteins during epithelial morphogenesis.
  • To investigate how E-cadherin redistribution impacts tissue remodeling.

Main Methods:

  • In vivo studies of epithelial morphogenesis.
  • Analysis of vesicle transport machinery.
  • Tracking of E-cadherin dynamics at the cell surface.

Main Results:

  • Junctional proteins, including E-cadherin, undergo dynamic turnover at the cell surface.
  • Spatially regulated endocytosis and exocytosis of E-cadherin influence cell adhesion and polarity.
  • Vesicle transport machinery plays a key role in epithelial cell rearrangement.

Conclusions:

  • Dynamic regulation of E-cadherin via vesicle transport is essential for epithelial morphogenesis.
  • Understanding these mechanisms provides insights into tissue development and organization.
  • The study highlights the importance of vesicle trafficking in maintaining tissue structure and function.