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Related Experiment Videos

Left ventricular function in patients with stable systemic lupus erythematosus.

K Enomoto1, Y Kaji, T Mayumi

  • 1First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Japanese Heart Journal
|July 1, 1991
PubMed
Summary

Systemic lupus erythematosus (SLE) patients exhibit impaired left ventricular diastolic function compared to healthy individuals. This diastolic dysfunction worsens with age, while systolic function remains unaffected in stable SLE.

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Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with potential cardiovascular implications.
  • Left ventricular (LV) function is crucial for overall cardiovascular health.
  • Understanding subclinical cardiac changes in SLE is vital for patient management.

Purpose of the Study:

  • To compare left ventricular (LV) systolic and diastolic function in female patients with stable SLE versus healthy controls.
  • To investigate the impact of age on LV function in SLE patients.

Main Methods:

  • Echocardiography was employed to assess LV function in 43 female SLE patients and 93 healthy females across three age groups.
  • Key parameters included left ventricular ejection fraction (systolic function) and diastolic descent rate of the anterior mitral leaflet (DDR), D/S ratio, and A/E ratio (diastolic function).

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Main Results:

  • No significant difference in left ventricular ejection fraction (systolic function) was observed between SLE patients and healthy controls.
  • Significant differences in diastolic function indices (DDR, D/S ratio, A/E ratio) were found in SLE patients compared to controls.
  • Diastolic dysfunction appeared to progressively worsen with increasing age in SLE patients.

Conclusions:

  • Patients with stable systemic lupus erythematosus demonstrate impaired left ventricular diastolic function compared to healthy individuals.
  • Left ventricular systolic function remains preserved in stable SLE.
  • Age is a significant factor in the progression of diastolic dysfunction in SLE patients.