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[Infant and pediatric heart transplantation: Loma Linda experience]
M Kawauchi1, S R Gundry, L L Bailey
1Department of Surgery, Loma Linda University Medical Center, California.
Insights
Pediatric heart transplantation outcomes show a 13% early and 11% late mortality rate. This procedure is a vital treatment for infants and children with fatal cardiac conditions.
Area of Science:
- Cardiology
- Pediatric Surgery
- Transplantation Medicine
Context:
- Between November 1985 and December 1990, 108 heart transplantations were performed on 106 infant and pediatric recipients at Loma Linda University Medical Center.
- The study population included 47 infants under one month, 46 children aged one month to two years, and 15 children over two years.
- Primary indications for transplantation were hypoplastic left heart syndrome (70 cases), complex congenital heart disease (17 cases), and cardiomyopathy (16 cases).
Purpose:
- To analyze the early and late outcomes of heart transplantation in infant and pediatric recipients.
- To evaluate the efficacy of heart transplantation for various pediatric cardiac conditions.
Summary:
- Overall early mortality was 13%, with late mortality at 11%.
- For infants under one month, early mortality was 13% and late mortality was 8%.
- Heart transplantation was deemed the primary treatment option for pediatric patients with otherwise fatal cardiac diseases.
Impact:
- This study highlights the critical role of heart transplantation in managing severe pediatric heart conditions.
- The findings provide valuable data for surgical teams and clinicians managing pediatric heart failure.
- It underscores the potential for successful outcomes in infant and pediatric heart transplantation, despite associated risks.
Abstract:
One hundred and six infant and pediatric recipients underwent 108 heart transplantation from November 1985 to December 1990 in Loma Linda University Medical Center. Forty-seven recipients were under one month of age at the time of transplantation, 46 from one month to 2 years and 15 over two years. Seventy recipients underwent heart transplantation under the diagnosis of hypoplastic left heart syndrome or the diseases equal to hypoplastic left heart syndrome, seventeen for complex congenital heart disease, sixteen for cardiomyopathy, and five for other reasons. Early mortality was 13% and late mortality was 11% for all cases. Early mortality for the infants under one month of age was 13% and late mortality was 8%. Heart transplantation was considered to be the treatment for choice for the patient with otherwise fatal cardiac diseases.