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No association between vitamin D receptor polymorphisms and coronary artery disease in a Chinese population

Xin-Min Pan1, Dong-Ri Li, Lan Yang

  • 1Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University , Chengdu, Peoples' Republic of China .

DNA and Cell Biology
|July 1, 2009
PubMed

Insights

Genetic factors influence coronary artery disease (CAD) risk. This study found no significant association between vitamin D receptor (VDR) gene polymorphisms (FokI and BsmI) and CAD in the Chinese population.

Area of Science:

  • Genetics
  • Cardiology
  • Molecular Biology

Background:

  • Clinical observations suggest a strong genetic predisposition to coronary artery disease (CAD).
  • The vitamin D receptor (VDR) gene is a potential candidate for influencing CAD susceptibility.
  • Specific polymorphisms in the VDR gene, FokI and BsmI, have been investigated for their role in various diseases.

Purpose of the Study:

  • To investigate the association between FokI (rs2228570) and BsmI (rs1544410) polymorphisms of the VDR gene and the risk of coronary artery disease (CAD).
  • To analyze genotype and allele frequencies of these VDR polymorphisms in a Chinese population with and without CAD.

Main Methods:

  • Case-control study design.
  • Genotyping of 152 CAD patients and 212 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for VDR FokI and BsmI polymorphisms.
  • Statistical analysis of genotype and allele frequencies.

Main Results:

  • No statistically significant differences were found in the genotype frequencies of FokI and BsmI polymorphisms between CAD patients and healthy controls.
  • Allele frequencies for both FokI and BsmI VDR gene polymorphisms did not show significant variation between the case and control groups.
  • Odds ratios for FokI (1.11) and BsmI (0.74) indicated no substantial association with CAD risk in this Chinese cohort.

Conclusions:

  • The FokI and BsmI polymorphisms in the vitamin D receptor (VDR) gene are not significantly associated with coronary artery disease (CAD) susceptibility in the studied Chinese population.
  • These specific VDR gene variants do not appear to be major genetic risk factors for CAD in this demographic.
  • Further research with larger cohorts and different populations may be warranted to fully elucidate the role of VDR gene variations in CAD.

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