Related Experiment Video
Updated: Jun 22, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
Published on: May 5, 2023
CTCF: master weaver of the genome
Jennifer E Phillips1, Victor G Corces
1Department of Biology, Emory University, Atlanta, GA 30322, USA. jephill@emory.edu
Abstract:
CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF-mediated intra- and interchromosomal contacts at several developmentally regulated genomic loci. These analyses support a primary role for CTCF in the global organization of chromatin architecture and suggest that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression.
Related Concept Videos
Master Transcription Regulators
Master Transcription Regulators
DNA as a Genetic Template
DNA as a Genetic Template
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Genomics

