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Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts
Published on: January 2, 2018
Time-dependent differential gene expression in lysophosphatidic acid-treated young and senescent human diploid
Ji-Heon Rhim1, Ik-Soon Jang, Jong-Soon Choi
1Department of Biochemistry and Molecular Biology, Ageing and Apoptosis Research Center, Seoul National University College of Medicine, Chongno-Gu, South Korea.
Abstract:
The gene expression profiles of lysophosphatidic acid (LPA)-treated young and senescent human diploid fibroblasts (HDFs) were examined using cDNA microarray analysis. The expression of some genes, including EGR 1/3 and MRRF, was controlled by LPA similarly in young and senescent cells, showing a typical time-dependent up-and-down expression profile. In contrast, some other genes, including DUSP6, CYR61, and F3, showed sustained upregulation in senescent HDFs later after LPA treatment. These genes might be involved in altered LPA responsiveness during the aging process.
