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Related Experiment Video

Updated: Jun 22, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

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Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis.

R T Naismith1, N T Tutlam, J Xu

  • 1Department of Neurology, Washington University, St Louis, MO 63110, USA. naismithr@neuro.wustl.edu

Neurology
|July 1, 2009
PubMed
Summary

Visual evoked potentials (VEP) are better than optical coherence tomography (OCT) for detecting optic neuritis (ON). OCT measures of retinal nerve fiber layer (RNFL) thickness correlate with vision but not overall disability.

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Area of Science:

  • Neuro-ophthalmology
  • Neuroscience
  • Medical imaging

Background:

  • Optic neuritis (ON) is an inflammatory condition affecting the optic nerve.
  • Assessing subclinical ON and its relationship to visual function and disease severity is crucial.
  • Optical coherence tomography (OCT) and visual evoked potentials (VEP) are used to evaluate optic nerve damage.

Purpose of the Study:

  • To determine the utility of OCT in detecting clinical and subclinical remote ON.
  • To explore the relationship between OCT findings, clinical ON characteristics, and visual function.
  • To assess if retinal nerve fiber layer (RNFL) thickness measured by OCT can serve as a surrogate marker for global disease severity.

Main Methods:

  • A cross-sectional study involving 65 subjects with a history of ON at least six months prior.
  • Data collected included clinical ON characteristics, visual acuity (VA), contrast sensitivity (CS), OCT, and VEP.
  • Analysis focused on the sensitivity of OCT and VEP in detecting ON and correlations between RNFL thickness and visual/clinical parameters.

Main Results:

  • VEP sensitivity (81%) was superior to OCT RNFL sensitivity (60%) for detecting ON.
  • Subclinical ON was present in 32% of unaffected eyes, predominantly identified by VEP.
  • RNFL thickness correlated with VA and CS but not with overall disability or demographic factors.

Conclusions:

  • VEP is the preferred method for detecting clinical and subclinical ON.
  • OCT measures of RNFL thickness are not reliable indicators of overall disability or prognostic factors in MS.
  • OCT can offer complementary data to VEP and is valuable for research in optic nerve diseases.