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Psoriasis--new insights into pathogenesis and treatment
Ulrich Mrowietz1, Kristian Reich
1Psoriasis-Zentrum, Abteilung Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 7, 24105 Kiel, Germany. umrowietz@dermatology.uni-kiel.de
Deutsches Arzteblatt International
|July 1, 2009
Summary
Psoriasis is a chronic inflammatory skin disease impacting millions. Following treatment guidelines and utilizing advanced therapies like biologics can significantly improve patient outcomes and quality of life.
Area of Science:
- Dermatology
- Inflammatory Diseases
- Public Health
Background:
- Psoriasis is a highly prevalent chronic inflammatory condition affecting approximately 2 million individuals in Germany.
- The disease presents with variable clinical manifestations and severity.
- Psoriasis is associated with a significant economic burden and increased risk of cardiovascular complications.
Purpose of the Study:
- To review current management strategies for psoriasis.
- To emphasize the importance of adhering to established treatment guidelines.
- To highlight the role of advanced therapies in managing refractory psoriasis.
Main Methods:
- A selective literature review was conducted.
- The review considered German S1 and S3 guidelines for psoriasis treatment.
Main Results:
- Psoriasis is a lifelong condition with a considerable impact on patients' lives.
- Psoriatic arthritis affects one in five patients.
- Biologics offer effective treatment options for patients unresponsive to conventional therapies.
Conclusions:
- Adherence to guidelines and comprehensive treatment approaches are crucial for effective psoriasis management.
- Biologics represent a significant advancement, improving skin status and quality of life.
- Integrated management strategies are essential for addressing the multifaceted nature of psoriasis.
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