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Updated: Jun 22, 2026

Spinal Cord Neurons Isolation and Culture from Neonatal Mice
Published on: July 11, 2017
[Protective effect of puerarin on the secondary spinal cord injury in rats]
Li-Song Heng1, Bin-Shang Lan, Zhen Jia
1Second Department of Orthopaedics, Second Affiliated Hospital, Medical School, Xi' an Jiaotong University, Xi' an 710004, China. henglisong1214@stu.xjtu.cdu.cn
Objective:
To research the protective effect of puerarin on secondary spinal cord injury (SCI) in rats.
Methods:
After the models of SCI were established by improved Allen's method on adult male SD rats, SOD, MDA, Bcl-2 and Bax gene protein expression between puerarin group and model group were compared after 1, 6, 12, 24 and 48 h.
Results:
Puerarin could significantly enhance the activity of SOD and reduce the content of MDA, increase the expression of Bcl-2 gene protein products and decrease Bax gene protein product.
Conclusions:
Puerarin can increase the activity of SOD, reduce the content of MDA, promote the expession of Bcl-2 and restrain the expression of Bax in the early spinal cord injury. It has protective effect on the secondary spinal cord injury.
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