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Capillary Electrophoresis to Monitor Peptide Grafting onto Chitosan Films in Real Time
Published on: October 26, 2016
Covalent insertion of antioxidant molecules on chitosan by a free radical grafting procedure
Manuela Curcio1, Francesco Puoci, Francesca Iemma
1Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende, CS 87036, Italy.
Abstract:
In this work, the synthesis of gallic acid-chitosan and catechin-chitosan conjugates was carried out by adopting a free radical-induced grafting procedure. For this purpose, an ascorbic acid/hydrogen peroxide redox pair was employed as radical initiator. The formation of covalent bonds between antioxidant and biopolymer was verified by performing UV, FT-IR, and DSC analyses, whereas the antioxidant properties of chitosan conjugates were compared with that of a blank chitosan, treated in the same conditions but in the absence of antioxidant molecules. The good antioxidant activity shown by functionalized materials proved the efficiency of the reaction method.
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