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Is there an association between hemangioma and syndromes with dysmorphic features?
A J Burns1, L C Kaplan, J B Mulliken
1Division of Plastic Surgery, Children's Hospital, Boston, Massachusetts 02115.
Pediatrics
|December 1, 1991
Summary
Most vascular birthmarks in newborns are macular stains, not hemangiomas, and often resolve. This review clarifies distinctions in vascular anomalies associated with dysmorphic syndromes.
Area of Science:
- Dermatology
- Genetics
- Pediatrics
Background:
- Vascular birthmarks are often misclassified as hemangiomas.
- Macular stains, like stork bites, are common in newborns.
- Accurate classification is crucial for understanding associated syndromes.
Purpose of the Study:
- To accurately define specific vascular anomalies in children with dysmorphic syndromes.
- To differentiate hemangiomas from other vascular lesions in syndromic newborns.
- To clarify the association between vascular anomalies and genetic syndromes.
Main Methods:
- Review of five standard genetics textbooks.
- Analysis of reported vascular anomalies in syndromic newborns.
- Clinical and cellular criteria for categorization of vascular birthmarks.
Main Results:
- The majority of vascular anomalies in syndromic newborns are macular stains, not hemangiomas.
- Most macular stains fade over time.
- Hemangiomas are incidentally associated with rare dysmorphic conditions and specific defects.
Conclusions:
- Vascular anomalies in dysmorphic syndromes are predominantly macular stains or malformations, not true hemangiomas.
- Hemangiomas have a limited association with specific rare dysmorphic conditions.
- Accurate diagnosis of vascular birthmarks is essential for syndromic diagnosis and management.
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