A Novel Neurocosmetic Postprocedure Cream for Optimal Recovery and Tolerability From Energy-Based Devices

Area of Science:

• Dermatology
• Cosmetic Science
• Regenerative Medicine

Background:

• Energy-based devices (EBDs) like hybrid fractional lasers (HFL) and fractional ablative CO2 lasers (FACL) are used for skin rejuvenation.
• Post-procedure care is crucial for managing side effects and optimizing results.
• A novel neurocosmetic post-procedure cream (NPPC) was developed to enhance recovery after EBD treatments.

Purpose of the Study:

• To evaluate the tolerability, safety, and efficacy of the NPPC following HFL and FACL treatments.
• To compare the NPPC's performance against conventional post-procedure topical routines.
• To assess patient compliance, retention, and satisfaction with the NPPC.

Main Methods:

• Two randomized, double-blinded, split-face, controlled studies were conducted on healthy females (35-65 years, Fitzpatrick Skin Types I-III) with moderate to severe photodamage.
• Subjects applied either NPPC or a comparator (moisturizer or anhydrous formulation) for 7 days (HFL) or 14 days (FACL) post-procedure.
• Tolerability, clinical photography, and questionnaires were used for assessments at baseline and post-procedure.

Main Results:

• The NPPC significantly improved erythema, edema, dryness, burning, itching, stinging, and discomfort.
• 91% of subjects reported "the product calmed my skin" by Day 1 post-FACL.
• No significant adverse events were reported; NPPC performed similarly or better than conventional topicals.

Conclusions:

• The NPPC is a safe and tolerable option for post-procedure care following HFL and FACL.
• It enhances skin healing, improves patient-reported outcomes, and demonstrates high patient retention.
• The NPPC offers comparable or superior results to conventional post-procedure routines.