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[Hormones and osteoporosis update. Vitamin D and bone]
Itsuro Endo1, Toshio Matsumoto
1Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences.
None:
Calcium homeostasis is maintained by parathyroid hormone and vitamin D. Mechanisms of action of these calcium-regulating hormones have been extensively examined, and the intracellular signaling pathways as well as transcriptional regulation of their target genes have been elucidated. Epidemiological studies revealed the importance of vitamin D sufficiency, and efforts have been made to implement the diagnostic criteria for vitamin D insufficiency. As a therapeutic agent, a new active vitamin D analog with anti-fracture efficacy has been developed for the treatment of osteoporosis.
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