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Plasma vitamins, amino acids, and renal function in postexercise hyperhomocysteinemia
Rafael Venta1, Elena Cruz, Gracia Valcárcel
1Service of Biochemistry, Hospital San Agustín, Avilés, Principado de Asturias, Spain. rafael.venta@sespa.princast.es
Medicine and Science in Sports and Exercise
|July 2, 2009
Summary
Intense exercise increases plasma homocysteine (Hcy) and cysteine levels, along with vitamin B12 and creatinine. These changes may be linked to altered renal function, not vitamin status or amino acid stress.
Area of Science:
- Exercise Physiology
- Biochemistry
- Clinical Nutrition
Background:
- Physical activity's impact on plasma homocysteine (Hcy) is debated.
- Mechanisms behind Hcy fluctuations post-exercise are unclear.
Purpose of the Study:
- Investigate acute aerobic exercise effects on plasma Hcy, cysteine, and related metabolites.
- Assess parallel impacts on renal function via plasma creatinine.
Main Methods:
- Examined 15 cyclists and 14 kayakers.
- Measurements taken pre- and post-specific maximal aerobic exercise.
Main Results:
- Significant increases observed in total Hcy (tHcy), reduced Hcy (rHcy), total Cys (tCys), and reduced Cys (rCys) post-exercise.
- Elevated plasma pyridoxal-5'-phosphate (PLP), vitamin B12, and creatinine noted.
- Correlations found between aminothiol changes and PLP, vitamin B12, and creatinine.
Conclusions:
- Post-exercise Hcy elevation is linked to rHcy increase, independent of exercise type or vitamin/amino acid status.
- Potential renal function changes may influence Hcy levels after intense exercise.
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