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Updated: Jun 22, 2026

Intracellular Refolding Assay
Published on: January 24, 2012
The small heat shock protein, HSPB6, in muscle function and disease
Catherine M Dreiza1, Padmini Komalavilas, Elizabeth J Furnish
1Capstone Therapeutics, Tempe, AZ 85281, USA. cparmiter@hotmail.com
Abstract:
The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications.
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