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Updated: Jun 22, 2026

Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG
Published on: March 10, 2017
An oscillatory circuit underlying the detection of disruptions in temporally-periodic patterns
Juan Gao1, Greg Schwartz, Michael J Berry
1Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA. juangao@stanford.edu
Abstract:
Neurons in diverse brain areas can respond to the interruption of a regular stimulus pattern by firing bursts of spikes. Here we describe a simple model, which permits such responses to periodic stimuli over a substantial frequency range. Focusing on the omitted stimulus response (OSR) in isolated retinas subjected to periodic patterns of dark flashes, we develop a biophysically-realistic model which accounts for resonances in ON bipolar cells. The bipolar cell terminal contains an LRC oscillator whose inductance is modulated by a transient calcium concentration, thus adjusting its resonant frequency to approximately match that of the stimulus. The model reproduces ganglion cell outputs, which sum the ON and OFF bipolar pathways, and it responds to omitted flashes with approximately constant latencies, as observed experimentally.
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