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Updated: Jun 22, 2026

Gramicidin-based Fluorescence Assay; for Determining Small Molecules Potential for Modifying Lipid Bilayer Properties
Published on: October 13, 2010
[Effect of lantibiotic warnerin on lipid bilayer membranes]
Abstract:
The effect of the lantibiotic warnerin on the ionic permeability of artificial membranes has been studied. Membranes were composed of different lipid fractions, including lipids isolated from warnerin-sensitive cells of Staphylococcus epidermidis. It was shown that warnerin selectively interacts with artificial membranes of different lipid composition, which leads, in some cases, to the formation of ionic channels. A computer model of the spatial structure of warnerin has been coustructed, which supports a high probability of the membranotropic activity of this peptide.
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