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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Consistent neuroanatomical age-related volume differences across multiple samples.

Kristine B Walhovd1, Lars T Westlye, Inge Amlien

  • 1Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway. k.b.walhovd@psykologi.uio.no

Neurobiology of Aging
|July 3, 2009
PubMed
Summary
This summary is machine-generated.

Magnetic resonance imaging (MRI) reveals widespread brain volume changes with aging. These structural differences in the aging brain are more consistent than previously thought.

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Aging Research

Background:

  • Magnetic resonance imaging (MRI) is crucial for studying in vivo brain aging.
  • Previous studies show inconsistent results regarding age-related structural brain changes.
  • Methodological variations and diverse aging patterns contribute to inconsistencies.

Purpose of the Study:

  • To investigate age-related volume changes in 17 neuroanatomical structures and total brain volume.
  • To assess the consistency of these age effects across multiple independent samples.
  • To clarify the pattern and extent of structural brain changes during healthy aging.

Main Methods:

  • Analysis of structural MRI data from 883 participants across five independent samples.
  • Examination of age effects on 17 specific neuroanatomical structures and total brain volume.
  • Investigation of consistency of findings across samples and assessment of non-linear age functions.

Main Results:

  • Consistent, widespread age-related volume differences were observed across samples for most brain structures.
  • Cerebral cortex, pallidum, putamen, and accumbens showed the strongest age-related volume reductions.
  • Total brain volume, white matter, caudate, hippocampus, and ventricles exhibited consistent non-linear aging patterns.

Conclusions:

  • Healthy aging is associated with more pervasive and consistent neuroanatomical volume differences than previously recognized.
  • Standardized MRI methods are essential for reliable understanding of brain aging.
  • Findings provide a more robust framework for studying structural brain changes in aging individuals.