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Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Evolutionary Relationships through Genome Comparisons

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Genomics

Genomics

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Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

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Related Experiment Video

Updated: Jun 22, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

JBrowse: a next-generation genome browser.

Mitchell E Skinner¹, Andrew V Uzilov, Lincoln D Stein

¹Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA.

Genome Research

|July 3, 2009

Summary

This summary is machine-generated.

JBrowse is an open-source JavaScript genome browser for web-based navigation of genome annotations. It offers smooth animations and reduces server load by distributing tasks between client and server.

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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Published on: August 15, 2019

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Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

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Published on: June 28, 2018

Area of Science:

Bioinformatics
Computational Biology
Genomics

Background:

Genome browsers are essential tools for navigating and visualizing genomic data.
Existing web-based genome browsers often suffer from performance issues and a disjointed user experience.

Purpose of the Study:

To introduce JBrowse, a novel open-source, JavaScript-based genome browser.
To enhance user experience through smooth navigation and reduce server overhead.

Main Methods:

Developed JBrowse using JavaScript for client-side rendering and interactivity.
Implemented smooth animations for panning, zooming, and track selection.
Distributed computational tasks between the web server and the client.

Main Results:

JBrowse provides a seamless user experience with fluid transitions.
Significantly reduced server overhead compared to traditional server-side rendering genome browsers.
Demonstrated efficient navigation of genome annotations over the web.

Conclusions:

JBrowse offers an efficient and user-friendly alternative for web-based genome browsing.
Its architecture optimizes performance and scalability for visualizing large genomic datasets.
A wiki plug-in facilitates easy sharing of annotation tracks.