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Updated: Jun 22, 2026

Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering
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Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering

Published on: March 1, 2016

Hydrogen-bonded layer-by-layer temperature-triggered release films.

Aliaksandr Zhuk1, Svetlana Pavlukhina, Svetlana A Sukhishvili

  • 1Department of Chemistry, Chemical Biology and Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey 07030, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|July 4, 2009
PubMed
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This study demonstrates temperature-responsive polymer multilayers built using layer-by-layer assembly. These films offer tunable pH stability and temperature-triggered release, showing promise for tissue engineering.

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomaterials Engineering

Background:

  • Layer-by-layer (LbL) assembly is a versatile technique for fabricating multilayer films.
  • Temperature-responsive polymers offer unique stimuli-responsive properties for advanced material applications.
  • Controlling film stability and release mechanisms is crucial for developing functional biomaterials.

Purpose of the Study:

  • To investigate the influence of temperature on the pH stability of hydrogen-bonded polymer multilayers.
  • To explore the use of temperature-responsive polymers for creating tunable and releasable multilayer films.
  • To develop novel strategies for fabricating free-floating films for potential tissue engineering applications.

Main Methods:

  • Fabrication of hydrogen-bonded multilayers using temperature-responsive polymers (PNIPAM, PVCL, PVME, PAAm) and polycarboxylic acids (PAA, PMAA, PEAA) via LbL assembly.

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  • Systematic evaluation of film stability under varying pH conditions and temperatures relative to polymer phase transition temperatures.
  • Construction of hybrid films incorporating temperature-responsive and non-responsive polymer layers for triggered release studies.
  • Utilizing PEAA for temperature-triggered film release at near-physiological pH.

    • Main Results:

    • Temperature during or after self-assembly significantly impacts multilayer film stability against pH changes.
    • Films exhibited enhanced pH stability when assembly temperature approached the polymer's critical temperature.
    • Polymers with lower critical solution temperature (LCST) showed increased pH stability with rising temperature (10-37°C), while upper critical solution temperature (UCST) polymers showed the opposite trend.
    • Hybrid films demonstrated temperature-triggered release of non-responsive layers by dissolving responsive layers.
    • Using PEAA enabled the construction of LbL films releasable by temperature at near-physiological pH.

    Conclusions:

    • Temperature plays a critical role in tuning the pH stability of hydrogen-bonded polymer multilayers.
    • The choice of polymer and assembly temperature allows for precise control over film properties.
    • Temperature-triggered release of LbL films, especially using PEAA at physiological pH, presents a promising platform for tissue engineering applications.