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Updated: Jun 22, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Nanostructured silica materials as drug-delivery systems for Doxorubicin: single molecule and cellular studies
Timo Lebold1, Christophe Jung, Jens Michaelis
1Department of Chemistry and Biochemistry, Center for Nanoscience (CeNS) and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universitat Munchen, 81377 Munich, Germany.
Abstract:
We apply mesoporous thin silica films with nanometer-sized pores as drug carriers and incorporate the widely used anticancer drug Doxorubicin. Through single-molecule based measurements, we gain mechanistic insights into the drug diffusion inside the mesoporous film, which governs the drug-delivery at the target-site. Drug dynamics inside the nanopores is controlled by pore size and surface modification. The release kinetics is determined and live-cell measurements prove the applicability of the system for drug-delivery. This study demonstrates that mesoporous silica nanomaterials can provide solutions for current challenges in nanomedicine.
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