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Updated: Jun 22, 2026
06:18
Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
Published on: March 13, 2018
Prophylaxis and therapy for Chikungunya virus infection
Thérèse Couderc1, Nassirah Khandoudi, Marc Grandadam
1Groupe Microorganismes et Barrières de l'Hôte and Unité Interactions Moléculaires Flavivirus-Hôtes, Centre National de Référence des Arbovirus, Institut Pasteur, Inserm, Avenir U604, and Université Paris Descartes, Hôpital Necker-Enfants Malades, Paris, France.
The Journal of Infectious Diseases
|July 4, 2009
Summary
Chikungunya virus (CHIKV) immunoglobulins show promise for preventing and treating CHIKV infection. This research offers a potential new therapy for at-risk individuals, including neonates and adults with underlying conditions.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Background:
- Chikungunya virus (CHIKV) is an emerging arbovirus with global spread potential.
- CHIKV infection typically causes fever, rash, and joint pain, but severe cases occur in neonates and adults with comorbidities.
Purpose of the Study:
- To investigate the preventive and curative effects of human polyvalent immunoglobulins against CHIKV infection.
- To evaluate the efficacy of CHIKV immunoglobulins in mouse models.
Main Methods:
- Purification of human polyvalent immunoglobulins from convalescent CHIKV-infected donors.
- Testing immunoglobulin efficacy in two developed mouse models of CHIKV infection.
Main Results:
- CHIKV immunoglobulins demonstrated high in vitro neutralizing activity.
- These immunoglobulins showed potent prophylactic and therapeutic efficacy in vivo, including in neonates.
Conclusions:
- CHIKV immunoglobulins represent a safe and effective strategy for preventing and treating CHIKV infection in high-risk populations.
- This study provides proof-of-concept for using convalescent plasma-derived immunoglobulins for emerging infectious diseases lacking treatments.
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