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Physiologically based models for bone-seeking elements. III. Human skeletal and bone growth.

E J O'Flaherty1

  • 1Department of Environmental Health, University of Cincinnati College of Medicine, Ohio 45267-0056.

Toxicology and Applied Pharmacology
|November 1, 1991
PubMed
Summary

A new model describes human skeletal and bone growth from birth to maturity using allometric equations. This model accurately reflects human bone composition and density, aiding in the study of bone-seeking elements.

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Area of Science:

  • Biomedical Engineering
  • Human Physiology
  • Skeletal Biology

Background:

  • Understanding human skeletal and bone growth is crucial for pediatric health and aging research.
  • Existing models often lack comprehensive inclusion of bone composition and growth dynamics.
  • Scaling data from animal models to humans presents significant challenges in bone and marrow physiology.

Purpose of the Study:

  • To develop a physiologically based model of human skeletal and bone growth from birth to maturity.
  • To incorporate key components such as dry/hydrated bone, bone marrow, ash, and calcium into the growth model.
  • To provide a framework adaptable for studying the kinetics of bone-seeking elements.

Main Methods:

  • Development of a mathematical model for skeletal and bone growth.

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  • Utilized allometric equations to relate skeletal component volume/weight to body weight.
  • Scaled blood flow rates from animal data, while acknowledging limitations for volume and growth patterns.

    • Main Results:

    • The model successfully describes the growth of the human skeleton and its fractions.
    • Incorporated dry and hydrated bone, bone marrow, ash, and calcium.
    • Model predictions show good agreement with measured human bone weights, ash weights, and skeletal densities.

    Conclusions:

    • The developed model provides a robust representation of human skeletal and bone growth.
    • The model's adaptability facilitates the study of bone-seeking element kinetics.
    • This work offers a valuable tool for research in skeletal biology and human physiology.