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Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
Published on: September 27, 2018
Review article: gastric electrical stimulation for gastroparesis--physiological foundations, technical aspects and
1Cedars Sinai Medical Center, Los Angeles, CA 90048, USA. edy.soffer@cshs.org
Alimentary Pharmacology & Therapeutics
|July 4, 2009
Summary
Gastric electrical stimulation (GES) offers a helpful intervention for difficult gastroparesis cases. Further research is needed to fully understand its mechanisms and optimize its therapeutic potential.
Area of Science:
- Gastroenterology
- Biomedical Engineering
Background:
- Electrical stimulation of the stomach has advanced significantly, moving from animal research to clinical applications.
- Gastroparesis is the primary approved indication for gastric electrical stimulation (GES).
Purpose of the Study:
- To review the physiological basis of gastric electrical activity.
- To examine the technical aspects and clinical outcomes of gastric electrical stimulation (GES) for gastroparesis.
Main Methods:
- Systematic review of literature using PubMed.
- Search terms included "gastroparesis" and "gastric electrical stimulation (GES)" from 1966 to 2009.
Main Results:
- Most studies are open-label, single-center reports from the last decade.
- GES reportedly improves symptoms, quality of life, and nutritional status in gastroparesis patients.
- Current GES parameters do not consistently regulate gastric slow waves or emptying; mechanisms involve biomechanical and neural modulation.
Conclusions:
- Gastric electrical stimulation (GES) is beneficial for refractory gastroparesis.
- More controlled studies are required to better understand GES mechanisms and clinical utility.
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