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Related Experiment Video

Updated: Jan 31, 2026

Fabrication of Zero Mode Waveguides for High Concentration Single Molecule Microscopy

Fabrication of Zero Mode Waveguides for High Concentration Single Molecule Microscopy

Published on: May 12, 2020

Sticky molecules in not-so-sticky cells.

M Hortsch¹, A J Bieber

¹Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor 48109-0616.

Trends in Biochemical Sciences

|August 1, 1991

Summary

Assigning roles to cell-surface proteins is challenging. Drosophila Schneider-2 (S2) cells offer a novel method for functional characterization of cell-adhesion molecules through transfection and aggregation assays.

Area of Science:

Cell biology
Molecular biology
Biochemistry

Background:

Standard methods for assigning cell-surface protein functions are often problematic.
Understanding cell-surface protein roles is crucial for biological processes.

Purpose of the Study:

To present a novel technique for functional characterization of cell-surface proteins.
To demonstrate the utility of Drosophila Schneider-2 (S2) cells in this process.

Main Methods:

Utilized Schneider-2 (S2) cells, a Drosophila cell line.
Performed cell transfection experiments.
Conducted cell aggregation assays.

Main Results:

S2 cells proved effective in transfection and aggregation experiments.

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The technique facilitated the functional characterization of putative cell-adhesion molecules.

Conclusions:

Drosophila S2 cells are a valuable tool for studying cell-surface protein function.
This method offers a viable approach for characterizing cell-adhesion molecules.